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This methylation profile is previously acquired at the MBL stage3 and continues to be somewhat steady with time. Nevertheless, some CLL have intratumor variability in certain locations, which may change the expression of various genes and facilitate tumor evolution.seventy one Of Observe, this variability is larger in U-CLL than in M-CLL and is affiliated with raising variety of subclones.7,seventy one

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Genetic susceptibility mechanisms. Most susceptibility loci map to non-coding regions on the genome, are mainly located in Lively promoters or enhancers, and modify the binding websites of a variety of transcription factors.

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